GB virus C/hepatitis G virus replicates in human haematopoietic cells and vascular endothelial cells
نویسندگان
چکیده
منابع مشابه
GB virus C/hepatitis G virus replicates in human haematopoietic cells and vascular endothelial cells.
A novel flavivirus, GB virus C (GBV-C)/hepatitis G virus (HGV), has been detected in chronic liver disease patients. It is known that the viral RNA can be detected in approximately 5% of American blood donors. However, the implications for liver disease and the sites of virus replication remain unknown. Possible sites of virus replication were studied by using cell lines and/or primary cells de...
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GB virus C (GBV-C), also known as hepatitis G virus, is a recently discovered flavivirus-like RNA agent with unclear pathogenic implications. To investigate whether human peripheral blood mononuclear cells (PBMC) are susceptible to in vitro GBV-C infection, we have incubated PBMC from four healthy blood donors with a human GBV-C RNA-positive serum. By means of (i) strand-specific reverse transc...
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متن کاملThe GB virus C/hepatitis G virus replicates in hepatocytes without causing liver disease in healthy blood donors.
Thirty-seven persons were identified with GB virus C (GBV-C) single infection by polymerase chain reaction screening of 1254 healthy blood donors. Of 33 donors who returned for clinical examination, 17 underwent liver biopsy. Clinical, biochemical, and histologic evaluation did not reveal any signs of liver disease. Liver biopsies of 15 donors were analyzed by in situ hybridization with GBV-C R...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 2000
ISSN: 0022-1317,1465-2099
DOI: 10.1099/0022-1317-81-10-2461